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Monday, May 18, 2020 | History

1 edition of Transcriptional regulation by Runt domain proteins in development and disease found in the catalog.

Transcriptional regulation by Runt domain proteins in development and disease

Transcriptional regulation by Runt domain proteins in development and disease

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  • 5 Currently reading

Published by Academic Press in London, UK .
Written in English

    Subjects:
  • Genetic transcription -- Regulation.,
  • Developmental genetics.,
  • Leukemia -- Genetic aspects.

  • Edition Notes

    Statementguest editor, Peter Gergen.
    SeriesSeminars in cell & developmental biology -- v. 11, no. 5.
    ContributionsGergen, John Peter.
    The Physical Object
    Paginationp. 325-382 :
    Number of Pages382
    ID Numbers
    Open LibraryOL15996980M

    Transcriptional repressor CTCF also known as zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

    Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics. How extracellular cues are transduced to the nucleus is a fundamental issue in biology. The paralogous WW-domain proteins YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif; also known as WWTR1, for WW-domain containing transcription regulator 1) constitute a pair of transducers linking cytoplasmic signaling events to transcriptional regulation in the nucleus.

    The first edition of the highly successful Transcriptional Regulation in Eukaryotes, written by Michael Carey and Stephen Smale at UCLA, provided a comprehensive source of strategic, conceptual, and technical information for investigating the complexities of gene regulation at the level of transcription. The VQ motif-containing proteins (designated as VQ proteins) are a class of plant-specific proteins with a conserved and single short FxxhVQxhTG amino acid sequence motif. VQ proteins regulate diverse developmental processes, including responses to biotic and abiotic stresses, seed development, and photomorphogenesis. In this Update, we summarize and discuss recent advances in our.


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Transcriptional regulation by Runt domain proteins in development and disease Download PDF EPUB FB2

Runt domain proteins have vital roles in regulating transcription in developmental pathways extending from sex determination and segmentation in fruit fly embryos to the development of blood and bone in by:   RUNX2, a member of the Runt family of transcription factors, plays important roles in embryonic development to promote osteogenesis and angiogenesis.

RUNX2 has been implicated in the promotion of disease, including cleidocranial dysplasia, in cancer progression, and in metastasis of breast and prostate by: 1. Runt domain proteins have vital roles in regulating transcription in developmental pathways extending from sex determination and segmentation in fruit fly embryos to the development of blood and bone in mammals.

Many of the insights into the mechanisms by which these proteins act to regulate transcription originate either from studies on the Drosophila runt gene, the founding member of this family, or from work on the mammalian PEBP2/CBF transcription by: Post-Transcriptional Regulation by STAR Proteins Control of RNA Metabolism in Development and Disease.

Editors (view affiliations) Talila Volk; Karen Artzt; Book. Citations; k Downloads; Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Log in to check access. Buy eBook.

USD Instant download. Runt domain proteins have vital roles in regulating transcription in developmental pathways extending from sex determination and segmentation in fruit fly embryos to the development of blood. The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer.

Interestingly, the Runt domain proteins act as both transcriptional activators and repressors, whereas, in contrast, the Hairy-related proteins appear to act only as transcriptional repressors (Aronson et al.

One possible explanation is that Groucho interacts constitutively with the WRPW motif in Hairy-related proteins, whereas the interaction with WRPY-containing Runt domain proteins is regulated.

modifications, which represent a major level of regulation of RUNX transcriptional activity. Importantly, deregulations of these subtle regulatory mechanisms have been shown to play important roles in the context of disease (Ito et al., ).

Auto-regulation, cross-regulation and functional redundancy. Here we describe that MOZ and MORF both interact with Runx2 (or Cbfa1), a Runt-domain transcription factor that is known to play important roles in T cell lymphomagenesis and bone development.

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Whereas mutations in the C-terminal domain were believed for some time to cluster within the RUNT domain, mutations in the C-terminal region, outside the RUNT domain. Proper functioning of these intricate networks is essential for the coordination of complex post-transcriptional events, and their perturbation can lead to disease (see Fig.

Download: Download high-res image (KB) Download: Download full-size image; Fig. The function of RBPs in the regulation of post-transcriptional gene expression. Transcription Factors and Human Disease Gregg L. Semenza Oxford Monographs on Medical Genetics.

Transcription Factors and Human Disease presents the basic science of transcriptional regulation and the inherited human diseases attributable to mutations in DNA sequences encoding transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is discussed.

Runt functions as a transcriptional regulator in multiple developmental pathways in Drosophila melanogaster. Recent evidence indicates that Runt represses the transcription of several downstream target genes in the segmentation pathway. Here we demonstrate that runt also functions to activate transcription.

The initial expression of the female-specific sex-determining gene Sex-lethal in the. The ‘Runt domain’ is an evolutionarily conserved domain located at the N-terminal site which derives its name from the fact that the pair rule gene.

runtDrosophila melanogaster. in is the founding member of the Runt domain family of transcription factors (Nusslein-Volard and Wieschaus, ). Runt domain proteins exhibit a high homology in. Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration.

Due to the strong link between RUNX2 and skeletal development, we hypothesized that the RUNT domain may be involved in the modulation of mechanisms associated with melanoma bone metastasis. Transcriptional regulation by transcription factors (TFs) and protein modification by protein kinases are involved in leaf inclination regulation.

OsLIGULELESS1 (OsLG1) encodes an SBP domain-containing TF, and mutant oslg1 abolishes the ligule, auricle, and lamina joint (Lee et al., ). Get this from a library. Post-transcriptional regulation by STAR proteins: control of RNA metabolism in development and disease.

[Talila Volk; Karen Jane Artzt;] -- This book aims to bring to the forefront a field that has been developing since the late s called the STAR pathway for Signal Transduction and Activation of RNA.

It is a signaling pathway that. RNA-Binding Proteins in Human Diseases—from Mechanisms to Therapies. An important regulatory mechanism of lncRNAs is the post-transcriptional regulation mediated by RNA-binding proteins (RBPs).

opinions and data contained in the journal International Journal of Molecular Sciences are solely those of the individual authors and. The ubiquitous components may be involved in regulating a variety of other tissue-specific proteins with bHLH domains. (c) Myc, one of many regulators of the cell cycle, is a bHLH protein.

It forms partners with Max, and it is possible that this is important in regulation of the cell cycle. Gergen, J.P. () Transcriptional regulation by Runt domain proteins in development and disease, Editorial Perspective (Guest Editor of this review volume), Seminars in Cell and Developmental Biology,   Therefore, cytokine-mediated MMP-1 and MMP gene regulation is an important issue in arthritis research.

In this review, we discuss current models of MMP-1 and MMP transcriptional regulation, with a focus on signaling intermediates and transcription factors that may be future targets for the development of new arthritis drugs.In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the right cell at the right time and in the right.